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  • J. L. Campbell

Comfort and Relief - This Cannabis-infused Mac & Cheese Recipe Has It All

When it comes to comfort food, you’d be hard pressed to find something that hits the spot like macaroni and cheese. Once you’ve had our cannabis-infused version of this classic dish, taking your medicine will never be the same. Grab your Missouri medical marijuana card and get ready to put together a shopping list! You can make a dish that’s probably a little different than mom used to make.

The History of Macaroni and Cheese

From breadcrumb-topped bakes at holiday gatherings to stovetop classics with powdered cheese in a pouch to pre-measured microwaveable bowls in college dorm rooms, mac and cheese is part of American culture.

Macaroni and cheese has been a staple of American cuisine since Thomas Jefferson popularized the dish, but its origins go back even further. The Food We Know examines the origins of mac and cheese and recorded that the earliest known recipe of a dish that combined pasta with cheese was in the 13th century. The cookbook was written by two chefs - one from France and the other from Italy - titled Liber de Coquina, but their dish featured lasagna-style noodles and not macaroni.

The first specific mention of macaroni and cheese was described in a recipe in 1769 in a book by Elizabeth Raffald called The Experienced English Housekeeper. Many people believe this dish was the origin of the macaroni and cheese that we eat today.

The dish spread across America when Thomas Jefferson served a macaroni and cheese pie at a state dinner. Things really took off in 1937 when the Kraft company began selling the boxed version that so many of us still eat today.

Now that you know how mac and cheese began, you’re ready to get started on a version of the recipe that Thomas Jefferson never tasted. Our recipe doesn’t just provide flavor and comfort but it also provides relief - the legal, natural relief that medical marijuana provides.

And our recipe isn’t some basic stovetop mac & cheese. There’s no pouch of yellow powder. Just like you deserve relief, you deserve flavor. This mac & cheese is gooey, topped with breadcrumbs, infused with cannabis, and baked in an oven. Let’s get started!

It’s All About the Cheese-To-Mac Ratio

When it comes to macaroni and cheese, I like mine gooey and chock-full of cheese. To do this, you can’t skimp on the dairy. PRO TIP: If possible, you’ll want to avoid pre-shredded cheese, and for the best results, buy your cheese in a block and shred it by hand. It’s worth the extra effort. Trust me!

This recipe is going to call for six cups of cheese, and you should feel free to alter the variety to your tastes. I prefer doing two cups of cheddar, two cups of Monterey Jack, and two cups of Swiss, but you should follow your heart and choose the cheese that best suits you.

Breadcrumbs Make the Dish

This is a southern-style mac and cheese bake. You may be tempted to skip the breadcrumbs, but I’m telling you they make a big difference in the flavor and texture. Easy Mac may have gotten me through college, but I’m an adult now, and I want a grown-up mac and cheese.

Cannabutter Is Your Secret Ingredient!

Cannabutter, a medical marijuana-infused butter, is the ingredient that takes this dish to the next level and adds the THC that provides relief. You can purchase premade cannabutter at a dispensary, but it’s also easy to make at home. Check out our guide on how to make your own cannabutter.

NOTE: In this recipe, I use 4 tbsp of cannabutter and two tbsp of regular butter. It’s important to note that medical marijuana affects people differently, so you may want to use more or less. If you want a higher dose, you may use 6 tbsp cannabutter, or if you’d like a lower dose, you could use as little as 1 tbsp cannabutter and then 5 tbsp regular butter. It’s up to you!


In order to make this medical-marijuana-infused macaroni and cheese, here’s what you’ll need:

  • 2 tsp Salt

  • 1 lb. elbow macaroni

  • 1 tbsp Olive Oil

  • 4 tbsp cannabutter

  • 2 tbsp butter

  • 2 cups cheddar cheese (shredded)

  • 2 cups monterey jack cheese (shredded)

  • 2 cups swiss cheese (shredded)

  • ⅓ cup flour

  • 2 1/2 cups whole milk

  • 1 1/2 cup heavy whipping cream

  • Salt and Pepper (to taste)

  • 2 cups panko breadcrumbs

  • ½ tsp Paprika


  1. Preheat your oven to 350 degrees.

  2. Take out a large baking dish and lightly grease it with butter or olive oil.

  3. Combine your shredded cheese varieties in a large mixing bowl.

  4. Pre-cook your macaroni. Remember - the macaroni is going to bake, so you don’t want to fully cook it at this stage. Different varieties of pasta are different, so examine the al-dente instructions on the package and cook it for about a minute less than that. Then, remove your pasta from the heat, drain, and set aside in a mixing bowl.

  5. Drizzle a tablespoon of olive oil over the pasta and stir it until it’s coated evently. Set aside.

  6. Melt your butter and cannabutter in a pot over medium heat.

  7. Add your flour to the butter/cannabutter mixture, whisking it for about a minute until it bubbles and becomes golden.

  8. Slowly whisk your heavy cream and milk until the mixture is combined evenly and the surface bubbles.

  9. Add salt and pepper and whisk for two more minutes.

  10. Take a wooden spoon and add in four cups of cheese, one cup at a time. Stir until the mixture is smooth, then add another cup. REMEMBER - you should still have two cups of cheese setting aside. You’ll need that to top the dish.

  11. Add your macaroni to the cheese sauce, stirring until it is coated evenly.

  12. Pour HALF of your macaroni and cheese into the baking dish and spread out evenly.

  13. Remember those two extra cups of cheese? Sprinkle them evenly over the pasta in the baking dish.

  14. Add the remainder of the macaroni and cheese on top and spread out evenly.

  15. In a smaller bowl, mix your breadcrumbs, paprika, and a tbsp of regular butter. Sprinkle these over the top of your baking dish.

  16. Place your dish into the oven and bake for 30 minutes.

  17. Enjoy responsibly!

If you enjoy cooking with cannabis, check, out our Easy-to-Bake THC-infused Edibles for Beginners Guide. And, if you’re already thinking ahead to summertime celebrations, you should take a look at our Cannabis Infused Recipes to help you celebrate the 4th of July!

You’ll Need a Medical Card Before You Bake Anything!

This recipe is delicious, but without your medical card, only the macaroni will be baked. You won’t be! If you need help getting your Missouri medical marijuana card, we’re here to help. Our doctors are standing by to take you through a quick and easy evaluation to see if you qualify. Schedule an appointment with a marijuana physician online by CLICKING HERE, or give us a call at (877) 303-3117 to talk to a patient support representative.


Doctors Who Care.

Relief You Can Trust.

At Missouri Marijuana Card, our mission is helping everyone achieve wellness safely and conveniently through increased access to medical marijuana. Our focus on education, inclusion, and acceptance will reduce the stigma for our patients by providing equal access to timely information and compassionate care.

Call us at (877) 303-3117, or simply book a medical marijuana evaluation to start getting relief you can trust today!

Check out Missouri Marijuana Card’s Blog to keep up to date on the latest medical marijuana news, tips, and information. Follow us on Facebook, Twitter, and Instagram to join the medical marijuana conversation in Missouri!

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